Class I(A) PI3Kinase regulatory subunit, p85α, mediates mast cell development through regulation of growth and survival related genes.

Class I(A) PI3Kinase regulatory subunit, p85α, mediates mast cell development through regulation of growth and survival related genes.

Stem cell factor (SCF) mediated KIT receptor activation plays a pivotal role in mast cell growth, maturation and survival. However, the signaling events downstream from KIT are poorly understood. Mast cells express multiple regulatory subunits of class 1(A) PI3Kinase (PI3K) including p85α, p85β, p50...

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Bibliographic Details
Main Authors: Subha Krishnan, Raghuveer Singh Mali, Karl R Koehler, Sasidhar Vemula, Anindya Chatterjee, Joydeep Ghosh, Baskar Ramdas, Peilin Ma, Eri Hashino, Reuben Kapur
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3251560?pdf=render

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