HSB-1 Inhibition and HSF-1 Overexpression Trigger Overlapping Transcriptional Changes To Promote Longevity in Caenorhabditis elegans

HSB-1 Inhibition and HSF-1 Overexpression Trigger Overlapping Transcriptional Changes To Promote Longevity in Caenorhabditis elegans

Heat shock factor 1 (HSF-1) is a component of the heat shock response pathway that is induced by cytoplasmic proteotoxic stress. In addition to its role in stress response, HSF-1 also acts as a key regulator of the rate of organismal aging. Overexpression of HSF-1 promotes longevity in C. elegans vi...

Full description

Bibliographic Details
Main Authors: Surojit Sural, Tzu-Chiao Lu, Seung Ah Jung, Ao-Lin Hsu
Format: Article
Language:English
Published: Oxford University Press 2019-05-01
Series:G3: Genes, Genomes, Genetics
Subjects:
C. elegans
heat shock factor
HSB-1
life span
RNA-Seq
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.119.400044

Internet

http://g3journal.org/lookup/doi/10.1534/g3.119.400044

Similar Items