Conditional inactivation of the DNA damage response gene Hus1 in mouse testis reveals separable roles for components of the RAD9-RAD1-HUS1 complex in meiotic chromosome maintenance.

Conditional inactivation of the DNA damage response gene Hus1 in mouse testis reveals separable roles for components of the RAD9-RAD1-HUS1 complex in meiotic chromosome maintenance.

The RAD9-RAD1-HUS1 (9-1-1) complex is a heterotrimeric PCNA-like clamp that responds to DNA damage in somatic cells by promoting DNA repair as well as ATR-dependent DNA damage checkpoint signaling. In yeast, worms, and flies, the 9-1-1 complex is also required for meiotic checkpoint function and eff...

Full description

Bibliographic Details
Main Authors: Amy M Lyndaker, Pei Xin Lim, Joanna M Mleczko, Catherine E Diggins, J Kim Holloway, Rebecca J Holmes, Rui Kan, Donald H Schlafer, Raimundo Freire, Paula E Cohen, Robert S Weiss
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3585019?pdf=render

Internet

http://europepmc.org/articles/PMC3585019?pdf=render

Similar Items