Circulating levels of tumor necrosis factor-alpha receptor 2 are increased in heart failure with preserved ejection fraction relative to heart failure with reduced ejection fraction: evidence for a divergence in pathophysiology.

Various pathways have been implicated in the pathogenesis of heart failure (HF) with preserved ejection fraction (HFPEF). Inflammation in response to comorbid conditions, such as hypertension and diabetes, may play a proportionally larger role in HFPEF as compared to HF with reduced ejection fractio...

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Bibliographic Details
Main Authors: Brendan N Putko, Zuocheng Wang, Jennifer Lo, Todd Anderson, Harald Becher, Jason R B Dyck, Zamaneh Kassiri, Gavin Y Oudit, Alberta HEART Investigators
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4055721?pdf=render