Phenotypic complementation of genetic immunodeficiency by chronic herpesvirus infection

Phenotypic complementation of genetic immunodeficiency by chronic herpesvirus infection

Variation in the presentation of hereditary immunodeficiencies may be explained by genetic or environmental factors. Patients with mutations in HOIL1 (RBCK1) present with amylopectinosis-associated myopathy with or without hyper-inflammation and immunodeficiency. We report that barrier-raised HOIL-1...

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Bibliographic Details
Main Authors: Donna A MacDuff, Tiffany A Reese, Jacqueline M Kimmey, Leslie A Weiss, Christina Song, Xin Zhang, Amal Kambal, Erning Duan, Javier A Carrero, Bertrand Boisson, Emmanuel Laplantine, Alain Israel, Capucine Picard, Marco Colonna, Brian T Edelson, L David Sibley, Christina L Stallings, Jean-Laurent Casanova, Kazuhiro Iwai, Herbert W Virgin
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-01-01
Series:eLife
Subjects:
Listeria monocytogene
murine gamma-herpesvirus 68
NF-kappaB
linear ubiquitination
immunodeficiency
Online Access:https://elifesciences.org/articles/04494

Internet

https://elifesciences.org/articles/04494

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