Nitroreductase Activites in <i>Giardia lamblia</i>: ORF 17150 Encodes a Quinone Reductase with Nitroreductase Activity

Nitroreductase Activites in <i>Giardia lamblia</i>: ORF 17150 Encodes a Quinone Reductase with Nitroreductase Activity

The intestinal diplomonadid <i>Giardia lamblia</i> is a causative agent of persistent diarrhea. Current treatments are based on nitro drugs, especially metronidazole. Nitro compounds are activated by reduction, yielding toxic intermediates. The enzymatic systems responsible for this acti...

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Bibliographic Details
Main Authors: Joachim Müller, Manfred Heller, Anne-Christine Uldry, Sophie Braga, Norbert Müller
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Pathogens
Subjects:
anaerobic metabolism
drug susceptibility
functional assays
mass spectrometry
protein chromatography
Online Access:https://www.mdpi.com/2076-0817/10/2/129

Internet

https://www.mdpi.com/2076-0817/10/2/129

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