Mapping T Cell Responses to Native and Neo-Islet Antigen Epitopes in at Risk and Type 1 Diabetes Subjects

Mapping T Cell Responses to Native and Neo-Islet Antigen Epitopes in at Risk and Type 1 Diabetes Subjects

AimsRecent studies highlight the potentially important role of neoepitopes in breaking immune tolerance in type 1 diabetes. T cell reactivity to these neoepitopes has been reported, but how this response compares quantitatively and phenotypically with previous reports on native epitopes is not known...

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Bibliographic Details
Main Authors: Sefina Arif, Irma Pujol-Autonell, Yogesh Kamra, Evangelia Williams, Norkhairin Yusuf, Clara Domingo-Vila, Yasaman Shahrabi, Emily Pollock, Leena Khatri, Mark Peakman, Timothy Tree, Anna Lorenc
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Immunology
Subjects:
neoepitopes
T cells
cytokines
T cell receptor
genes
type 1 diabetes
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.675746/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.675746/full

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