Enhanced intestinal lymphatic absorption of saquinavir through supersaturated self-microemulsifying drug delivery systems

Enhanced intestinal lymphatic absorption of saquinavir through supersaturated self-microemulsifying drug delivery systems

The therapeutic potential of saquinavir, a specific inhibitor of human immunodeficiency virus (HIV)-1 and HIV-2 protease enzymes, has been largely limited because of a low solubility and consequnt low bioavailability. Thus, we aimed to design a supersaturated self-microemulsifying drug delivery syst...

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Bibliographic Details
Main Authors: Kanghee Jo, Hyeongmin Kim, Prakash Khadka, Taejun Jang, Soo Jin Kim, Seong-Ha Hwang, Jaehwi Lee
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Asian Journal of Pharmaceutical Sciences
Subjects:
Lymphatic drug delivery
Self-microemulsifying drug delivery system
Saquinavir
Precipitation inhibitor
Supersaturation
Lipid-based formulation
Online Access:http://www.sciencedirect.com/science/article/pii/S1818087618308134

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http://www.sciencedirect.com/science/article/pii/S1818087618308134

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