Type I interferon signaling is required for the APOBEC3/Rfv3-dependent neutralizing antibody response but not innate retrovirus restriction

Type I interferon signaling is required for the APOBEC3/Rfv3-dependent neutralizing antibody response but not innate retrovirus restriction

Abstract Background APOBEC3/Rfv3 restricts acute Friend retrovirus (FV) infection and promotes virus-specific neutralizing antibody (NAb) responses. Classical Rfv3 studies utilized FV stocks containing lactate-dehydrogenase elevating virus (LDV), a potent type I interferon inducer. Previously, we sh...

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Bibliographic Details
Main Authors: Bradley S. Barrett, Michael S. Harper, Sean T. Jones, Kejun Guo, Karl J. Heilman, Ross M. Kedl, Kim J. Hasenkrug, Mario L. Santiago
Format: Article
Language:English
Published: BMC 2017-04-01
Series:Retrovirology
Subjects:
IFNAR
Friend retrovirus
Neutralizing antibody
Deaminase
LDV
Online Access:http://link.springer.com/article/10.1186/s12977-017-0349-2

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http://link.springer.com/article/10.1186/s12977-017-0349-2

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