Synthesis and evaluation of 2,4,5-trisubstitutedthiazoles as carbonic anhydrase-III inhibitors

Synthesis and evaluation of 2,4,5-trisubstitutedthiazoles as carbonic anhydrase-III inhibitors

A series of 17 compounds (12–16 b) with 2,4,5-trisubstitutedthiazole scaffold having 5-aryl group, 4-carboxylic acid/ester moiety, and 2-amino/amido/ureido functional groups were synthesised, characterised, and evaluated for their carbonic anhydrase (CA)-III inhibitory activities using the size excl...

Full description

Bibliographic Details
Main Authors: Bilal A. Al-Jaidi, Pran Kishore Deb, Soha Taher Telfah, Abdel Naser Dakkah, Yazan A. Bataineh, Qutaiba Ahmed Al Khames Aga, Mohammad A. Al-dhoun, Ala’ Ali Ahmad Al-Subeihi, Haifa’a Marouf Odetallah, Sanaa K. Bardaweel, Raghuprasad Mailavaram, Katharigatta N. Venugopala, Anroop B. Nair
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
carbonic anhydrase iii inhibitors
2-amino-5-aryl-thiazole
hummel–dreyer method of chromatography
Online Access:http://dx.doi.org/10.1080/14756366.2020.1786820

Internet

http://dx.doi.org/10.1080/14756366.2020.1786820

Similar Items