Assessment of transcriptomic constraint-based methods for central carbon flux inference

Motivation Determining intracellular metabolic flux through isotope labeling techniques such as 13C metabolic flux analysis (13C-MFA) incurs significant cost and effort. Previous studies have shown transcriptomic data coupled with constraint-based metabolic modeling can determine intracellular fluxe...

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Bibliographic Details
Main Authors: Siddharth Bhadra-Lobo, Min Kyung Kim, Desmond S. Lun, Rajagopal Subramanyam
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7480874/?tool=EBI