GNA11 Q209L Mouse Model Reveals RasGRP3 as an Essential Signaling Node in Uveal Melanoma

GNA11 Q209L Mouse Model Reveals RasGRP3 as an Essential Signaling Node in Uveal Melanoma

Summary: Uveal melanoma (UM) is characterized by mutually exclusive activating mutations in GNAQ, GNA11, CYSLTR2, and PLCB4, four genes in a linear pathway to activation of PLCβ in almost all tumors and loss of BAP1 in the aggressive subset. We generated mice with melanocyte-specific expression of G...

Full description

Bibliographic Details
Main Authors: Amanda R. Moore, Leili Ran, Youxin Guan, Jessica J. Sher, Tyler D. Hitchman, Jenny Q. Zhang, Catalina Hwang, Edward G. Walzak, Alexander N. Shoushtari, Sébastien Monette, Rajmohan Murali, Thomas Wiesner, Klaus G. Griewank, Ping Chi, Yu Chen
Format: Article
Language:English
Published: Elsevier 2018-02-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718301451

Internet

http://www.sciencedirect.com/science/article/pii/S2211124718301451

Similar Items