PARP-1 inhibitors: are they the long-sought genetically specific drugs for BRCA1/2-associated breast cancers?
<p>Recent studies demonstrated that PARP-1 [poly(ADP-ribose) polymerase-1] inhibitors kill breast cancer associated gene-1 and –2 (BRCA1/2) deficient cells with extremely high efficiency while BRCA+/- and BRCA+/+ cells are relatively non-responsive to the treatment. It was therefore...
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| Format: | Article |
| Language: | English |
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Ivyspring International Publisher
2006-01-01
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| Series: | International Journal of Medical Sciences |
| Online Access: | http://www.medsci.org/v03p0117.htm |