Hypoxic Preconditioning Maintains GLT-1 against Transient Global Cerebral Ischemia through Upregulating Cx43 and Inhibiting c-Src

Hypoxic Preconditioning Maintains GLT-1 against Transient Global Cerebral Ischemia through Upregulating Cx43 and Inhibiting c-Src

Transient global cerebral ischemia (tGCI) causes excessive release of glutamate from neurons. Astrocytic glutamate transporter-1 (GLT-1) and glutamine synthetase (GS) together play a predominant role in maintaining glutamate at normal extracellular concentrations. Though our previous studies reporte...

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Bibliographic Details
Main Authors: Kong ping Li, Hua rong Zhou, Li xuan Zhan, Zhe Shi, Wei wen Sun, Dan dan Liu, Liu Liu, Dong hai Liang, Ya fu Tan, Wen sheng Xu, En Xu
Format: Article
Language:English
Published: Frontiers Media S.A.
Series:Frontiers in Molecular Neuroscience
Subjects:
Glutamate transporter 1
glutamine synthetase
Connexin 43
c-src
cerebral ischemia
hypoxic preconditioning
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00344/full

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https://www.frontiersin.org/article/10.3389/fnmol.2018.00344/full

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