High-Sensitivity Fluorometry to Resolve Ion Channel Conformational Dynamics

Summary: Fluorescent labels offer the capability to follow conformational dynamics of membrane proteins, but signal detection in such recordings is inherently difficult to achieve in a cell membrane and lacks sufficient time resolution to follow physiologically relevant transitions. Here, we develop...

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Bibliographic Details
Main Authors: Matthias Wulf, Stephan Alexander Pless
Format: Article
Language:English
Published: Elsevier 2018-02-01
Series:Cell Reports
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718300615