Nestin Promotes Peritoneal Fibrosis by Protecting HIF1-α From Proteasomal Degradation

Nestin Promotes Peritoneal Fibrosis by Protecting HIF1-α From Proteasomal Degradation

BackgroundPeritoneal dialysis (PD) is a treatment for end stage renal disease patients, but it can also cause peritoneal fibrosis. Nestin is known as a neural stem cell marker and it has many functions. The hypoxia induced factor (HIF) signaling pathway can be activated under hypoxia conditions, lea...

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Bibliographic Details
Main Authors: Yangping Shentu, Huanchang Jiang, Xiaoyuan Liu, Hao Chen, Dicheng Yang, Jinqi Zhang, Chen Cheng, Yulin Zheng, Yang Zhang, Chaosheng Chen, Chenfei Zheng, Ying Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Physiology
Subjects:
peritoneal dialysis
peritoneal fibrosis
angiogenesis
HIF1-α pathway
nestin
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2020.517912/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2020.517912/full

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