A Novel Orthotopic Liver Cancer Model for Creating a Human-like Tumor Microenvironment

A Novel Orthotopic Liver Cancer Model for Creating a Human-like Tumor Microenvironment

Hepatocellular carcinoma (HCC) is the most common form of liver cancer. This study aims to develop a new method to generate an HCC mouse model with a human tumor, and imitates the tumor microenvironment (TME) of clinical patients. Here, we have generated functional, three-dimensional sheet-like huma...

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Bibliographic Details
Main Authors: Rong Qiu, Soichiro Murata, Chao Cheng, Akihiro Mori, Yunzhong Nie, Satoshi Mikami, Shunsuke Hasegawa, Tomomi Tadokoro, Satoshi Okamoto, Hideki Taniguchi
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cancers
Subjects:
hepatocellular carcinoma
animal model
tumor microenvironment
fibrosis
ultra-purified alginate gel
Online Access:https://www.mdpi.com/2072-6694/13/16/3997

Internet

https://www.mdpi.com/2072-6694/13/16/3997

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