Sublethal RNA Oxidation as a Mechanism for Neurodegenerative Disease

Sublethal RNA Oxidation as a Mechanism for Neurodegenerative Disease

Although cellular RNA is subjected to the same oxidative insults as DNA and other cellular macromolecules, oxidative damage to RNA has not been a major focus in investigations of the biological consequences of free radical damage. In fact, because it is largely single-stranded and its bases lack the...

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Bibliographic Details
Main Authors: Mark A. Smith, George Perry, Atsushi Takeda, Paula I. Moreira, Raj K. Rolston, Akihiko Nunomura, Rudy J. Castellani
Format: Article
Language:English
Published: MDPI AG 2008-05-01
Series:International Journal of Molecular Sciences
Subjects:
Alzheimer disease
8-oxoguanosine
neurodegeneration
oxidative damage
Parkinson disease
RNA
Online Access:http://www.mdpi.com/1422-0067/9/5/789/

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http://www.mdpi.com/1422-0067/9/5/789/

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