GH dysfunction in Engrailed-2 knockout mice, a model for autism spectrum disorders

GH dysfunction in Engrailed-2 knockout mice, a model for autism spectrum disorders

Insulin-like growth factor 1 (IGF-1) signaling promotes brain development and plasticity. Altered IGF-1 expression has been associated to autism spectrum disorders (ASD). IGF-1 levels were found increased in the blood and decreased in the cerebrospinal fluid of ASD children. Accordingly, IGF-1 treat...

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Bibliographic Details
Main Authors: Giovanni eProvenzano, Elena eClementi, Sacha eGenovesi, Manuela eScali, Prem Prakash Tripathi, Paola eSgadò, Yuri eBozzi
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-09-01
Series:Frontiers in Pediatrics
Subjects:
Growth Hormone
Hippocampus
Liver
Pituitary Gland
Autism Spectrum Disorders
mouse model
Online Access:http://journal.frontiersin.org/Journal/10.3389/fped.2014.00092/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fped.2014.00092/full

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