Genomic Evolution in a Patient With Lung Adenocarcinoma With a Germline EGFR T790M Mutation

Genomic Evolution in a Patient With Lung Adenocarcinoma With a Germline EGFR T790M Mutation

Introduction: A subset of lung adenocarcinomas (ADs) has been found to have somatic activating mutations in the tyrosine kinase domain of the EGFR gene, associated with response to EGFR tyrosine kinase inhibitor therapy. Rare germline mutations within this domain, including EGFR T790M, have been ass...

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Bibliographic Details
Main Authors: Netta Mäkinen, PhD, Meng Zhou, PhD, Meredith Bemus, BS, Julius Nevin, BS, Anwesha Nag, PhD, Ruthia Chen, BA, Yolonda L. Colson, MD, PhD, Aaron R. Thorner, PhD, Geoffrey R. Oxnard, MD, Matthew Meyerson, MD, PhD, Lynette M. Sholl, MD
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:JTO Clinical and Research Reports
Subjects:
NSCLC
Lung adenocarcinoma
EGFR germline mutation
High-throughput sequencing
Genome evolution
Online Access:http://www.sciencedirect.com/science/article/pii/S2666364321000059

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http://www.sciencedirect.com/science/article/pii/S2666364321000059

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