A Novel Missense Mutation in <i>TNNI3K</i> Causes Recessively Inherited Cardiac Conduction Disease in a Consanguineous Pakistani Family

A Novel Missense Mutation in <i>TNNI3K</i> Causes Recessively Inherited Cardiac Conduction Disease in a Consanguineous Pakistani Family

Cardiac conduction disease (CCD), which causes altered electrical impulse propagation in the heart, is a life-threatening condition with high morbidity and mortality. It exhibits genetic and clinical heterogeneity with diverse pathomechanisms, but in most cases, it disrupts the synchronous activity...

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Bibliographic Details
Main Authors: Shafaq Ramzan, Stephanie Tennstedt, Muhammad Tariq, Sheraz Khan, Hafiza Noor Ul Ayan, Aamir Ali, Matthias Munz, Holger Thiele, Asad Aslam Korejo, Abdul Razzaq Mughal, Syed Zahid Jamal, Peter Nürnberg, Shahid Mahmood Baig, Jeanette Erdmann, Ilyas Ahmad
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Genes
Subjects:
TNNI3K
missense mutation
molecular modeling simulation
cardiac conduction
Online Access:https://www.mdpi.com/2073-4425/12/8/1282

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https://www.mdpi.com/2073-4425/12/8/1282

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