Adrecizumab, a non-neutralizing anti-adrenomedullin antibody, improves haemodynamics and attenuates myocardial oxidative stress in septic rats

Adrecizumab, a non-neutralizing anti-adrenomedullin antibody, improves haemodynamics and attenuates myocardial oxidative stress in septic rats

Abstract Background Sepsis still represents a major health issue, with persistent high morbidity and mortality rates. Cardiovascular dysfunction occurs frequently during sepsis. Adrenomedullin has been identified as a key mediator in vascular tone regulation. A non-neutralizing anti-adrenomedullin a...

Full description

Bibliographic Details
Main Authors: Alice Blet, Benjamin Deniau, Christopher Geven, Malha Sadoune, Anaïs Caillard, Paul-Robert Kounde, Evelyne Polidano, Peter Pickkers, Jane-Lise Samuel, Alexandre Mebazaa
Format: Article
Language:English
Published: SpringerOpen 2019-05-01
Series:Intensive Care Medicine Experimental
Online Access:http://link.springer.com/article/10.1186/s40635-019-0255-0

Internet

http://link.springer.com/article/10.1186/s40635-019-0255-0

Similar Items