Adrecizumab, a non-neutralizing anti-adrenomedullin antibody, improves haemodynamics and attenuates myocardial oxidative stress in septic rats
Abstract Background Sepsis still represents a major health issue, with persistent high morbidity and mortality rates. Cardiovascular dysfunction occurs frequently during sepsis. Adrenomedullin has been identified as a key mediator in vascular tone regulation. A non-neutralizing anti-adrenomedullin a...
Main Authors: | Alice Blet, Benjamin Deniau, Christopher Geven, Malha Sadoune, Anaïs Caillard, Paul-Robert Kounde, Evelyne Polidano, Peter Pickkers, Jane-Lise Samuel, Alexandre Mebazaa |
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Format: | Article |
Language: | English |
Published: |
SpringerOpen
2019-05-01
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Series: | Intensive Care Medicine Experimental |
Online Access: | http://link.springer.com/article/10.1186/s40635-019-0255-0 |
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