A selective HDAC 1/2 inhibitor modulates chromatin and gene expression in brain and alters mouse behavior in two mood-related tests.

A selective HDAC 1/2 inhibitor modulates chromatin and gene expression in brain and alters mouse behavior in two mood-related tests.

Psychiatric diseases, including schizophrenia, bipolar disorder and major depression, are projected to lead global disease burden within the next decade. Pharmacotherapy, the primary--albeit often ineffective--treatment method, has remained largely unchanged over the past 50 years, highlighting the...

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Bibliographic Details
Main Authors: Frederick A Schroeder, Michael C Lewis, Daniel M Fass, Florence F Wagner, Yan-Ling Zhang, Krista M Hennig, Jennifer Gale, Wen-Ning Zhao, Surya Reis, Douglas D Barker, Erin Berry-Scott, Sung Won Kim, Elizabeth L Clore, Jacob M Hooker, Edward B Holson, Stephen J Haggarty, Tracey L Petryshen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3743770?pdf=render

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http://europepmc.org/articles/PMC3743770?pdf=render

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