Assessment of the Effects of MPTP and Paraquat on Dopaminergic Neurons and Microglia in the Substantia Nigra Pars Compacta of C57BL/6 Mice.

Assessment of the Effects of MPTP and Paraquat on Dopaminergic Neurons and Microglia in the Substantia Nigra Pars Compacta of C57BL/6 Mice.

The neurotoxicity of paraquat dichloride (PQ) was assessed in two inbred strains of 9- or 16-week old male C57BL/6 mice housed in two different laboratories and compared to the effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). PQ was administered by intraperitoneal injections; either o...

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Bibliographic Details
Main Authors: Richard Jay Smeyne, Charles B Breckenridge, Melissa Beck, Yun Jiao, Mark T Butt, Jeffrey C Wolf, Dan Zadory, Daniel J Minnema, Nicholas C Sturgess, Kim Z Travis, Andrew R Cook, Lewis L Smith, Philip A Botham
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5082881?pdf=render

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http://europepmc.org/articles/PMC5082881?pdf=render

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