Mechanism of inhibition of taurolithocholate‐induced retrieval of plasma membrane MRP2 by cyclic AMP and tauroursodeoxycholate

Mechanism of inhibition of taurolithocholate‐induced retrieval of plasma membrane MRP2 by cyclic AMP and tauroursodeoxycholate

Abstract Taurolithocholate (TLC) produces cholestasis by inhibiting biliary solute secretion in part by retrieving MRP2 from the plasma membrane (PM). Tauroursodeoxycholate (TUDC) and cAMP reverse TLC‐induced cholestasis by inhibiting TLC‐induced retrieval of MRP2. However, cellular mechanisms for t...

Full description

Bibliographic Details
Main Authors: Se Won Park, Cynthia R. L. Webster, Mohammed S. Anwer
Format: Article
Language:English
Published: Wiley 2017-12-01
Series:Physiological Reports
Subjects:
Cholestasis
HuH‐NTCP cells
MARCKS phosphorylation
PKC ε
rat hepatocytes
Online Access:https://doi.org/10.14814/phy2.13529

Internet

https://doi.org/10.14814/phy2.13529

Similar Items