Investigating the potential role of genetic and epigenetic variation of DNA methyltransferase genes in hyperplastic polyposis syndrome.

Investigating the potential role of genetic and epigenetic variation of DNA methyltransferase genes in hyperplastic polyposis syndrome.

Hyperplastic Polyposis Syndrome (HPS) is a condition associated with multiple serrated polyps, and an increased risk of colorectal cancer (CRC). At least half of CRCs arising in HPS show a CpG island methylator phenotype (CIMP), potentially linked to aberrant DNA methyltransferase (DNMT) activity. C...

Full description

Bibliographic Details
Main Authors: Musa Drini, Nicholas C Wong, Hamish S Scott, Jeffrey M Craig, Alexander Dobrovic, Chelsee A Hewitt, Christofer Dow, Joanne P Young, Mark A Jenkins, Richard Saffery, Finlay A Macrae
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-02-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3037390?pdf=render

Internet

http://europepmc.org/articles/PMC3037390?pdf=render

Similar Items