Ezh2-dCas9 and KRAB-dCas9 enable engineering of epigenetic memory in a context-dependent manner

Ezh2-dCas9 and KRAB-dCas9 enable engineering of epigenetic memory in a context-dependent manner

Abstract Background Rewriting of the epigenome has risen as a promising alternative to gene editing for precision medicine. In nature, epigenetic silencing can result in complete attenuation of target gene expression over multiple mitotic divisions. However, persistent repression has been difficult...

Full description

Bibliographic Details
Main Authors: Henriette O’Geen, Sofie L. Bates, Sakereh S. Carter, Karly A. Nisson, Julian Halmai, Kyle D. Fink, Suhn K. Rhie, Peggy J. Farnham, David J. Segal
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Epigenetics & Chromatin
Subjects:
Epigenetic memory
Epigenome editing
CRISPR–dCas9
Ezh2
Epigenetics
Histone methylation
Online Access:http://link.springer.com/article/10.1186/s13072-019-0275-8

Internet

http://link.springer.com/article/10.1186/s13072-019-0275-8

Similar Items