1-O-Sulfatobastadins-1 and -2 from Ianthella basta (Pallas).Antagonists of the yR1-FKBP12 Ca2+ Channel

1-O-Sulfatobastadins-1 and -2 from Ianthella basta (Pallas).Antagonists of the yR1-FKBP12 Ca2+ Channel

Abstract: Two new sulfate monoesters of hemibastadins-1 and -2 were isolated from the marine sponge Ianthella basta (Pallas) from Guam. A third new compound was tentatively assigned the structure 34-O-sulfatobastadin-9. The 1-O-sulfatohemibastadins-1 and –2 were antagonists of the RyR1-FKBP12 C...

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Bibliographic Details
Main Authors: Tadeusz F. Molinski, Isaac N. Pessah, Alexander C. Hoepker, Makoto N. Masuno
Format: Article
Language:English
Published: MDPI AG 2004-11-01
Series:Marine Drugs
Subjects:
Bromotyrosine
calcium channel
Porifera
ryanodine receptor
Online Access:http://www.mdpi.com/1660-3397/2/4/176/
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spelling doaj-f9b5ed81d861454b977f3402f159cb652020-11-24T21:12:11ZengMDPI AGMarine Drugs1660-33972004-11-012417618410.3390/md2041761-O-Sulfatobastadins-1 and -2 from Ianthella basta (Pallas).Antagonists of the yR1-FKBP12 Ca2+ ChannelTadeusz F. MolinskiIsaac N. PessahAlexander C. HoepkerMakoto N. MasunoAbstract: Two new sulfate monoesters of hemibastadins-1 and -2 were isolated from the marine sponge Ianthella basta (Pallas) from Guam. A third new compound was tentatively assigned the structure 34-O-sulfatobastadin-9. The 1-O-sulfatohemibastadins-1 and –2 were antagonists of the RyR1-FKBP12 Ca2+ channel under conditions where the known compound bastadin-5 exhibits potent agonism (EC50 2μM).http://www.mdpi.com/1660-3397/2/4/176/Bromotyrosinecalcium channelPoriferaryanodine receptor
collection DOAJ
language English
format Article
sources DOAJ
author Tadeusz F. Molinski
Isaac N. Pessah
Alexander C. Hoepker
Makoto N. Masuno
spellingShingle Tadeusz F. Molinski
Isaac N. Pessah
Alexander C. Hoepker
Makoto N. Masuno
1-O-Sulfatobastadins-1 and -2 from Ianthella basta (Pallas).Antagonists of the yR1-FKBP12 Ca2+ Channel
Marine Drugs
Bromotyrosine
calcium channel
Porifera
ryanodine receptor
author_facet Tadeusz F. Molinski
Isaac N. Pessah
Alexander C. Hoepker
Makoto N. Masuno
author_sort Tadeusz F. Molinski
title 1-O-Sulfatobastadins-1 and -2 from Ianthella basta (Pallas).Antagonists of the yR1-FKBP12 Ca2+ Channel
title_short 1-O-Sulfatobastadins-1 and -2 from Ianthella basta (Pallas).Antagonists of the yR1-FKBP12 Ca2+ Channel
title_full 1-O-Sulfatobastadins-1 and -2 from Ianthella basta (Pallas).Antagonists of the yR1-FKBP12 Ca2+ Channel
title_fullStr 1-O-Sulfatobastadins-1 and -2 from Ianthella basta (Pallas).Antagonists of the yR1-FKBP12 Ca2+ Channel
title_full_unstemmed 1-O-Sulfatobastadins-1 and -2 from Ianthella basta (Pallas).Antagonists of the yR1-FKBP12 Ca2+ Channel
title_sort 1-o-sulfatobastadins-1 and -2 from ianthella basta (pallas).antagonists of the yr1-fkbp12 ca2+ channel
publisher MDPI AG
series Marine Drugs
issn 1660-3397
publishDate 2004-11-01
description Abstract: Two new sulfate monoesters of hemibastadins-1 and -2 were isolated from the marine sponge Ianthella basta (Pallas) from Guam. A third new compound was tentatively assigned the structure 34-O-sulfatobastadin-9. The 1-O-sulfatohemibastadins-1 and –2 were antagonists of the RyR1-FKBP12 Ca2+ channel under conditions where the known compound bastadin-5 exhibits potent agonism (EC50 2μM).
topic Bromotyrosine
calcium channel
Porifera
ryanodine receptor
url http://www.mdpi.com/1660-3397/2/4/176/
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AT isaacnpessah 1osulfatobastadins1and2fromianthellabastapallasantagonistsoftheyr1fkbp12ca2channel
AT alexanderchoepker 1osulfatobastadins1and2fromianthellabastapallasantagonistsoftheyr1fkbp12ca2channel
AT makotonmasuno 1osulfatobastadins1and2fromianthellabastapallasantagonistsoftheyr1fkbp12ca2channel
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