1-O-Sulfatobastadins-1 and -2 from Ianthella basta (Pallas).Antagonists of the yR1-FKBP12 Ca2+ Channel
Abstract: Two new sulfate monoesters of hemibastadins-1 and -2 were isolated from the marine sponge Ianthella basta (Pallas) from Guam. A third new compound was tentatively assigned the structure 34-O-sulfatobastadin-9. The 1-O-sulfatohemibastadins-1 and –2 were antagonists of the RyR1-FKBP12 C...
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2004-11-01
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Online Access: | http://www.mdpi.com/1660-3397/2/4/176/ |
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doaj-f9b5ed81d861454b977f3402f159cb652020-11-24T21:12:11ZengMDPI AGMarine Drugs1660-33972004-11-012417618410.3390/md2041761-O-Sulfatobastadins-1 and -2 from Ianthella basta (Pallas).Antagonists of the yR1-FKBP12 Ca2+ ChannelTadeusz F. MolinskiIsaac N. PessahAlexander C. HoepkerMakoto N. MasunoAbstract: Two new sulfate monoesters of hemibastadins-1 and -2 were isolated from the marine sponge Ianthella basta (Pallas) from Guam. A third new compound was tentatively assigned the structure 34-O-sulfatobastadin-9. The 1-O-sulfatohemibastadins-1 and –2 were antagonists of the RyR1-FKBP12 Ca2+ channel under conditions where the known compound bastadin-5 exhibits potent agonism (EC50 2μM).http://www.mdpi.com/1660-3397/2/4/176/Bromotyrosinecalcium channelPoriferaryanodine receptor |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tadeusz F. Molinski Isaac N. Pessah Alexander C. Hoepker Makoto N. Masuno |
spellingShingle |
Tadeusz F. Molinski Isaac N. Pessah Alexander C. Hoepker Makoto N. Masuno 1-O-Sulfatobastadins-1 and -2 from Ianthella basta (Pallas).Antagonists of the yR1-FKBP12 Ca2+ Channel Marine Drugs Bromotyrosine calcium channel Porifera ryanodine receptor |
author_facet |
Tadeusz F. Molinski Isaac N. Pessah Alexander C. Hoepker Makoto N. Masuno |
author_sort |
Tadeusz F. Molinski |
title |
1-O-Sulfatobastadins-1 and -2 from Ianthella basta (Pallas).Antagonists of the yR1-FKBP12 Ca2+ Channel |
title_short |
1-O-Sulfatobastadins-1 and -2 from Ianthella basta (Pallas).Antagonists of the yR1-FKBP12 Ca2+ Channel |
title_full |
1-O-Sulfatobastadins-1 and -2 from Ianthella basta (Pallas).Antagonists of the yR1-FKBP12 Ca2+ Channel |
title_fullStr |
1-O-Sulfatobastadins-1 and -2 from Ianthella basta (Pallas).Antagonists of the yR1-FKBP12 Ca2+ Channel |
title_full_unstemmed |
1-O-Sulfatobastadins-1 and -2 from Ianthella basta (Pallas).Antagonists of the yR1-FKBP12 Ca2+ Channel |
title_sort |
1-o-sulfatobastadins-1 and -2 from ianthella basta (pallas).antagonists of the yr1-fkbp12 ca2+ channel |
publisher |
MDPI AG |
series |
Marine Drugs |
issn |
1660-3397 |
publishDate |
2004-11-01 |
description |
Abstract: Two new sulfate monoesters of hemibastadins-1 and -2 were isolated from the marine sponge Ianthella basta (Pallas) from Guam. A third new compound was tentatively assigned the structure 34-O-sulfatobastadin-9. The 1-O-sulfatohemibastadins-1 and –2 were antagonists of the RyR1-FKBP12 Ca2+ channel under conditions where the known compound bastadin-5 exhibits potent agonism (EC50 2μM). |
topic |
Bromotyrosine calcium channel Porifera ryanodine receptor |
url |
http://www.mdpi.com/1660-3397/2/4/176/ |
work_keys_str_mv |
AT tadeuszfmolinski 1osulfatobastadins1and2fromianthellabastapallasantagonistsoftheyr1fkbp12ca2channel AT isaacnpessah 1osulfatobastadins1and2fromianthellabastapallasantagonistsoftheyr1fkbp12ca2channel AT alexanderchoepker 1osulfatobastadins1and2fromianthellabastapallasantagonistsoftheyr1fkbp12ca2channel AT makotonmasuno 1osulfatobastadins1and2fromianthellabastapallasantagonistsoftheyr1fkbp12ca2channel |
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