Upregulation of Spinal ASIC1 and NKCC1 Expression Contributes to Chronic Visceral Pain in Rats

Upregulation of Spinal ASIC1 and NKCC1 Expression Contributes to Chronic Visceral Pain in Rats

Aims: To determine whether acid-sensing ion channel 1 (ASIC1)–sodium-potassium-chloride cotransporter 1 (NKCC1) signaling pathway participates in chronic visceral pain of adult rats with neonatal maternal deprivation (NMD).Methods: Chronic visceral pain was detected by colorectal distension (CRD). W...

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Bibliographic Details
Main Authors: Yong-Chang Li, Yuan-Qing Tian, Yan-Yan Wu, Yu-Cheng Xu, Ping-An Zhang, Jie Sha, Guang-Yin Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Molecular Neuroscience
Subjects:
visceral pain
neonatal maternal deprivation
spinal dorsal horn
ASIC1
NKCC1
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2020.611179/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2020.611179/full

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