PGC-1-related coactivator modulates mitochondrial-nuclear crosstalk through endogenous nitric oxide in a cellular model of oncocytic thyroid tumours.

PGC-1-related coactivator modulates mitochondrial-nuclear crosstalk through endogenous nitric oxide in a cellular model of oncocytic thyroid tumours.

BACKGROUND:The PGC-1 related coactivator (PRC), which shares structural and functional features with PGC-1alpha, is believed to regulate several metabolic pathways as well as mitochondrial biogenesis. Its involvement in the early programming of cell proliferation suggests the existence of finely reg...

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Main Authors: Mahatsangy Raharijaona, Soazig Le Pennec, Julie Poirier, Delphine Mirebeau-Prunier, Clothilde Rouxel, Caroline Jacques, Jean-Fred Fontaine, Yves Malthiery, Rémi Houlgatte, Frédérique Savagner
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-11-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2776512?pdf=render

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http://europepmc.org/articles/PMC2776512?pdf=render

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