Impacts of High Intra- and Inter-Individual Variability in Tacrolimus Pharmacokinetics and Fast Tacrolimus Metabolism on Outcomes of Solid Organ Transplant Recipients

Impacts of High Intra- and Inter-Individual Variability in Tacrolimus Pharmacokinetics and Fast Tacrolimus Metabolism on Outcomes of Solid Organ Transplant Recipients

Tacrolimus is a first-line calcineurin inhibitor (CNI) and an integral part of the immunosuppressive strategy in solid organ transplantation. Being a dose-critical drug, tacrolimus has a narrow therapeutic index that necessitates periodic monitoring to maintain the drug’s efficacy and reduce the con...

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Bibliographic Details
Main Authors: Charat Thongprayoon, Panupong Hansrivijit, Karthik Kovvuru, Swetha R. Kanduri, Tarun Bathini, Aleksandra Pivovarova, Justin R. Smith, Wisit Cheungpasitporn
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Journal of Clinical Medicine
Subjects:
tacrolimus
calcineurin inhibitors
FK506
transplantation
kidney transplantation
immunosuppression
Online Access:https://www.mdpi.com/2077-0383/9/7/2193

Internet

https://www.mdpi.com/2077-0383/9/7/2193

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