Distinct genomic integration of MLV and SIV vectors in primate hematopoietic stem and progenitor cells.

Distinct genomic integration of MLV and SIV vectors in primate hematopoietic stem and progenitor cells.

Murine leukemia virus (MLV)-derived vectors are widely used for hematopoietic stem cell (HSC) gene transfer, but lentiviral vectors such as the simian immunodeficiency virus (SIV) may allow higher efficiency transfer and better expression. Recent studies in cell lines have challenged the notion that...

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Bibliographic Details
Main Authors: Peiman Hematti, Bum-Kee Hong, Cole Ferguson, Rima Adler, Hideki Hanawa, Stephanie Sellers, Ingeborg E Holt, Craig E Eckfeldt, Yugal Sharma, Manfred Schmidt, Christof von Kalle, Derek A Persons, Eric M Billings, Catherine M Verfaillie, Arthur W Nienhuis, Tyra G Wolfsberg, Cynthia E Dunbar, Boris Calmels
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2004-12-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.0020423

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https://doi.org/10.1371/journal.pbio.0020423

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