Receptor-mediated enhancement of beta adrenergic drug activity by ascorbate in vitro and in vivo.

RATIONALE: Previous in vitro research demonstrated that ascorbate enhances potency and duration of activity of agonists binding to alpha 1 adrenergic and histamine receptors. OBJECTIVES: Extending this work to beta 2 adrenergic systems in vitro and in vivo. METHODS: Ultraviolet spectroscopy was used...

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Bibliographic Details
Main Authors: Patrick F Dillon, Robert Root-Bernstein, N Edward Robinson, William M Abraham, Catherine Berney
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3001466?pdf=render