Nebivolol Desensitizes Myofilaments of a Hypertrophic Cardiomyopathy Mouse Model
Background: Hypertrophic cardiomyopathy (HCM) patients often present with diastolic dysfunction and a normal to supranormal systolic function. To counteract this hypercontractility, guideline therapies advocate treatment with beta-adrenoceptor and Ca2+ channel blockers. One well established pathomec...
Main Authors: | Sabrina Stücker, Nico Kresin, Lucie Carrier, Felix W. Friedrich |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2017-08-01
|
Series: | Frontiers in Physiology |
Subjects: | |
Online Access: | http://journal.frontiersin.org/article/10.3389/fphys.2017.00558/full |
Similar Items
-
Analysis of Contractile Function of Permeabilized Human Hypertrophic Cardiomyopathy Multicellular Heart Tissue
by: Nico Kresin, et al.
Published: (2019-03-01) -
Epigallocatechin-3-gallate accelerates relaxation and Ca2+ transient decay and desensitizes myofilaments in healthy and Mybpc3-targeted knock-in cardiomyopathic mice
by: Felix W. Friedrich, et al.
Published: (2016-12-01) -
Familial hypertrophic cardiomyopathy: A case with a new mutation in the MYBPC3 gene
by: Olgu Hallioglu Kilinc, et al.
Published: (2017-07-01) -
Proteasome inhibition slightly improves cardiac function in mice with hypertrophic cardiomyopathy
by: Saskia eSchlossarek, et al.
Published: (2014-12-01) -
Repair of Mybpc3 mRNA by 5′-trans-splicing in a Mouse Model of Hypertrophic Cardiomyopathy
by: Giulia Mearini, et al.
Published: (2013-01-01)