Cholesteryl ester hydrolase activity is abolished in HSL macrophages but unchanged in macrophages lacking KIAA1363[S]

Cholesteryl ester hydrolase activity is abolished in HSL macrophages but unchanged in macrophages lacking KIAA1363[S]

Cholesteryl ester (CE) accumulation in macrophages represents a crucial event during foam cell formation, a hallmark of atherogenesis. Here we investigated the role of two previously described CE hydrolases, hormone-sensitive lipase (HSL) and KIAA1363, in macrophage CE hydrolysis. HSL and KIAA1363 e...

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Bibliographic Details
Main Authors: Marlene Buchebner, Thomas Pfeifer, Nora Rathke, Prakash G. Chandak, Achim Lass, Renate Schreiber, Adelheid Kratzer, Robert Zimmermann, Wolfgang Sattler, Harald Koefeler, Eleonore Fröhlich, Gerhard M. Kostner, Ruth Birner-Gruenberger, Kyle P. Chiang, Guenter Haemmerle, Rudolf Zechner, Sanja Levak-Frank, Benjamin Cravatt, Dagmar Kratky
Format: Article
Language:English
Published: Elsevier 2010-10-01
Series:Journal of Lipid Research
Subjects:
2-acetyl monoalkylglycerol ether hydrolase
cholesterol metabolism
lipase
lipids
triacylglycerol
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520409794

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http://www.sciencedirect.com/science/article/pii/S0022227520409794

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