Enhanced mPGES-1 Contributes to PD-Related Peritoneal Fibrosis via Activation of the NLRP3 Inflammasome

Enhanced mPGES-1 Contributes to PD-Related Peritoneal Fibrosis via Activation of the NLRP3 Inflammasome

Background: Microsomal prostaglandin E synthase-1 (mPGES-1)-derived prostaglandin E2 (PGE2) is a chief mediator of inflammation. However, the role and mechanism of mPGES-1 in peritoneal dialysis (PD)-associated peritoneal fibrosis have not been investigated.Material and Methods: In PD patients, mPGE...

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Bibliographic Details
Main Authors: Qimei Luo, Qinghua Hu, Qingkun Zheng, Lewei Gong, Lijuan Su, Baojun Ren, Yongle Ju, Zhanjun Jia, Xianrui Dou
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Medicine
Subjects:
mPGES-1
PGE2
peritoneal fibrosis
inflammation
NLRP3 inflammasome
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2021.675363/full

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https://www.frontiersin.org/articles/10.3389/fmed.2021.675363/full

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