HIV-1 conserved elements p24CE DNA vaccine induces humoral immune responses with broad epitope recognition in macaques.

HIV-1 conserved elements p24CE DNA vaccine induces humoral immune responses with broad epitope recognition in macaques.

To target immune responses towards invariable regions of the virus, we engineered DNA-based immunogens encoding conserved elements (CE) of HIV-1 p24gag. This conserved element vaccine is designed to avoid decoy epitopes by focusing responses to critical viral elements. We previously reported that va...

Full description

Bibliographic Details
Main Authors: Viraj Kulkarni, Antonio Valentin, Margherita Rosati, Morgane Rolland, James I Mullins, George N Pavlakis, Barbara K Felber
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4206485?pdf=render

Internet

http://europepmc.org/articles/PMC4206485?pdf=render

Similar Items