LAT2 regulates glutamine-dependent mTOR activation to promote glycolysis and chemoresistance in pancreatic cancer

LAT2 regulates glutamine-dependent mTOR activation to promote glycolysis and chemoresistance in pancreatic cancer

Abstract Background Reprogrammed energy metabolism has become an emerging hallmark of cancer in recent years. Transporters have been reported to be amino acid sensors involved in controlling mTOR recruitment and activation, which is crucial for the growth of both normal and tumor cells. L-type amino...

Full description

Bibliographic Details
Main Authors: Mengyu Feng, Guangbing Xiong, Zhe Cao, Gang Yang, Suli Zheng, Jiangdong Qiu, Lei You, Lianfang Zheng, Taiping Zhang, Yupei Zhao
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
L-type amino acid transporter 2
Mechanistic target of rapamycin
Pancreatic cancer
Chemoresistance
Glutamine metabolism
Glycolysis
Online Access:http://link.springer.com/article/10.1186/s13046-018-0947-4

Internet

http://link.springer.com/article/10.1186/s13046-018-0947-4

Similar Items