Effects of PDE3 Inhibitor Olprinone on the Respiratory Parameters, Inflammation, and Apoptosis in an Experimental Model of Acute Respiratory Distress Syndrome

Effects of PDE3 Inhibitor Olprinone on the Respiratory Parameters, Inflammation, and Apoptosis in an Experimental Model of Acute Respiratory Distress Syndrome

This study aimed to investigate whether a selective phosphodiesterase-3 (PDE3) inhibitor olprinone can positively influence the inflammation, apoptosis, and respiratory parameters in animals with acute respiratory distress syndrome (ARDS) model induced by repetitive saline lung lavage. Adult rabbits...

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Bibliographic Details
Main Authors: Petra Kosutova, Pavol Mikolka, Sona Balentova, Marian Adamkov, Andrea Calkovska, Daniela Mokra
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:International Journal of Molecular Sciences
Subjects:
olprinone
lung injury
inflammation
apoptosis
oxidative stress
PDE3
Online Access:https://www.mdpi.com/1422-0067/21/9/3382

Internet

https://www.mdpi.com/1422-0067/21/9/3382

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