Viral Vector-Based Innovative Approaches to Directly Abolishing Tumorigenic Pluripotent Stem Cells for Safer Regenerative Medicine

Viral Vector-Based Innovative Approaches to Directly Abolishing Tumorigenic Pluripotent Stem Cells for Safer Regenerative Medicine

Human pluripotent stem cells (hPSCs) are a promising source of regenerative material for clinical applications. However, hPSC transplant therapies pose the risk of teratoma formation and malignant transformation of undifferentiated remnants. These problems underscore the importance of developing tec...

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Bibliographic Details
Main Authors: Kaoru Mitsui, Kanako Ide, Tomoyuki Takahashi, Ken-ichiro Kosai
Format: Article
Language:English
Published: Elsevier 2017-06-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
adenoviral conditional targeting
conditionally replicating adenovirus
oncolytic virus
pluripotent stem cells
regenerative medicine
suicide gene
survivin
teratoma
tumorigenicity
viral vector
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050117300475

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http://www.sciencedirect.com/science/article/pii/S2329050117300475

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