HAP40 protein levels are huntingtin-dependent and decrease in Huntington disease

HAP40 protein levels are huntingtin-dependent and decrease in Huntington disease

The huntingtin-associated protein 40 (HAP40) is an abundant interactor of huntingtin (HTT). In complexes of these proteins, HAP40 tightly binds to HTT in a cleft formed by two larger domains rich in HEAT repeats, and a smaller bridge domain connecting the two.We show that HAP40 steady-state protein...

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Bibliographic Details
Main Authors: Bin Huang, Manuel Seefelder, Eva Buck, Tatjana Engler, Katrin S. Lindenberg, Fabrice Klein, G. Bernhard Landwehrmeyer, Stefan Kochanek
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:Neurobiology of Disease
Subjects:
HAP40
Huntingtin
Huntington disease
Protein stability
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Online Access:http://www.sciencedirect.com/science/article/pii/S0969996121002254

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http://www.sciencedirect.com/science/article/pii/S0969996121002254

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