P.58 Genetic Background Dictates Aortic Fibrosis in Hypertensive Mice

P.58 Genetic Background Dictates Aortic Fibrosis in Hypertensive Mice

Background: Many genetic mutations affect aortic structure and function in mice, but little is known about the influence of background strain. We compared the biomechanical, structural, and gene expression responses of C57BL/6J and 129SvEv aortas to angiotensin II (AngII)-induced hypertension. Meth...

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Bibliographic Details
Main Authors: Bart Spronck, Marcos Latorre, Sameet Mehta, Alexander W. Caulk, Abhay B. Ramachandra, Sae-Il Murtada, Alexia Rojas, Chang-Sun He, Bo Jiang, Mo Wang, Matthew R. Bersi, George Tellides, Jay D. Humphrey
Format: Article
Language:English
Published: Atlantis Press 2020-12-01
Series:Artery Research
Subjects:
Stiffness
smooth muscle
inflammation
Online Access:https://www.atlantis-press.com/article/125950088/view

Internet

https://www.atlantis-press.com/article/125950088/view

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