Shikonin Derivatives from <i>Onsoma visianii</i> Decrease Expression of Phosphorylated STAT3 in Leukemia Cells and Exert Antitumor Activity

Shikonin Derivatives from <i>Onsoma visianii</i> Decrease Expression of Phosphorylated STAT3 in Leukemia Cells and Exert Antitumor Activity

Antitumor effects of shikonins on chronic lymphocytic leukemia (CLL) and B-cell prolymphocytic leukemia (B-PLL) are mostly unexplored. The antitumor activity of shikonins, isolated from <i>Onosma visianii</i> Clem (<i>Boraginaceae</i>), in BCL1, mouse CLL cells and JVM-13, hu...

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Bibliographic Details
Main Authors: Zeljko Todorovic, Jelena Milovanovic, Dragana Arsenijevic, Nenad Vukovic, Milena Vukic, Aleksandar Arsenijevic, Predrag Djurdjevic, Marija Milovanovic, Nebojsa Arsenijevic
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Nutrients
Subjects:
isobutyrylshikonin
α-methylbutyrylshikonin
<i>Onosma visianii</i>
STAT3
BCL1
JVM-13
Online Access:https://www.mdpi.com/2072-6643/13/4/1147

Internet

https://www.mdpi.com/2072-6643/13/4/1147

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