A novel synthetic approach to hydroimidazo[1,5-b]pyridazines by the recyclization of itaconimides and HPLC–HRMS monitoring of the reaction pathway

A novel synthetic approach to hydroimidazo[1,5-b]pyridazines by the recyclization of itaconimides and HPLC–HRMS monitoring of the reaction pathway

The novel cascade two-stage reaction between itaconimides and 1,2-diamino-4-phenylimidazole proceeds regio- and chemoselectively to form tetrahydroimidazo[1,5-b]pyridazines and includes nucleophilic C-addition by the activated C=C double bond and subsequent intramolecular recyclization of the interm...

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Bibliographic Details
Main Authors: Dmitry Yu. Vandyshev, Khidmet S. Shikhaliev, Andrey Yu. Potapov, Michael Yu. Krysin, Fedor I. Zubkov, Lyudmila V. Sapronova
Format: Article
Language:English
Published: Beilstein-Institut 2017-11-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
cascade reaction
diaminoimidazoles
HPLC–HRESIMS
imidazo[1,5-b]pyridazines
itaconimides
Online Access:https://doi.org/10.3762/bjoc.13.252

Internet

https://doi.org/10.3762/bjoc.13.252

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