CD8+ T Cells Form the Predominant Subset of NKG2A+ Cells in Human Lung Cancer

CD8+ T Cells Form the Predominant Subset of NKG2A+ Cells in Human Lung Cancer

Background: NKG2A is an inhibitory receptor of both T cells and natural killer (NK) cells. Persistent activation promotes T cells and NK cells to express NKG2A and results in the progression of chronic infection and cancer. However, the characteristics and subsets of NKG2A+ lymphocytes in human lung...

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Bibliographic Details
Main Authors: Yongyuan Chen, Zhongwei Xin, Lijian Huang, Lufeng Zhao, Shijie Wang, Jiwei Cheng, Pin Wu, Ying Chai
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Immunology
Subjects:
NKG2A
CD8+ T cells
non-small cell lung cancer
T-cell dysfunction
immune checkpoints
tumor microenvironment
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.03002/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.03002/full

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