Hedgehog inhibition mediates radiation sensitivity in mouse xenograft models of human esophageal adenocarcinoma.

Hedgehog inhibition mediates radiation sensitivity in mouse xenograft models of human esophageal adenocarcinoma.

BACKGROUND:The Hedgehog (Hh) signaling pathway is active in esophageal adenocarcinoma (EAC). We used a patient-derived murine xenograft (PDX) model of EAC to evaluate tumour response to conventional treatment with radiation/chemoradiation with or without Hh inhibition. Our goal was to determine the...

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Bibliographic Details
Main Authors: Jennifer Teichman, Lorin Dodbiba, Henry Thai, Andrew Fleet, Trevor Morey, Lucy Liu, Madison McGregor, Dangxiao Cheng, Zhuo Chen, Gail Darling, Yonathan Brhane, Yuyao Song, Osvaldo Espin-Garcia, Wei Xu, Hala Girgis, Joerg Schwock, Helen MacKay, Robert Bristow, Laurie Ailles, Geoffrey Liu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5929523?pdf=render

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http://europepmc.org/articles/PMC5929523?pdf=render

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