Exosomes secreted by palmitic acid-treated hepatocytes promote LX-2 cell activation by transferring miRNA-107

Abstract Activation of hepatic stellate cells (HSCs) is a key inducer of liver fibrogenesis in nonalcoholic fatty liver disease (NAFLD). Exosomes play an important role between hepatocytes and HSCs. This study aims to explore the role of exosomes derived from palmitic acid (PA)-treated hepatocytes i...

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Bibliographic Details
Main Authors: Wei Wang, Fangfang Li, Xiaoyang Lai, Han Liu, Shuting Wu, Yunqin Han, Yunfeng Shen
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-021-00536-7