Maternal Exercise Mediates Hepatic Metabolic Programming via Activation of AMPK-PGC1α Axis in the Offspring of Obese Mothers

Maternal Exercise Mediates Hepatic Metabolic Programming via Activation of AMPK-PGC1α Axis in the Offspring of Obese Mothers

Maternal obesity is associated with an increased risk of hepatic metabolic dysfunction for both mother and offspring and targeted interventions to address this growing metabolic disease burden are urgently needed. This study investigates whether maternal exercise (ME) could reverse the detrimental e...

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Bibliographic Details
Main Authors: Philipp Kasper, Saida Breuer, Thorben Hoffmann, Christina Vohlen, Ruth Janoschek, Lisa Schmitz, Sarah Appel, Gregor Fink, Christoph Hünseler, Alexander Quaas, Münevver Demir, Sonja Lang, Hans-Michael Steffen, Anna Martin, Christoph Schramm, Martin Bürger, Esther Mahabir, Tobias Goeser, Jörg Dötsch, Eva Hucklenbruch-Rother, Inga Bae-Gartz
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cells
Subjects:
NAFLD
metabolic health
AMPK
gestational exercise
perinatal programming
Online Access:https://www.mdpi.com/2073-4409/10/5/1247

Internet

https://www.mdpi.com/2073-4409/10/5/1247

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