Quality Control Strategy for CRISPR-Cas9-Based Gene Editing Complicated by a Pseudogene

Quality Control Strategy for CRISPR-Cas9-Based Gene Editing Complicated by a Pseudogene

CRISPR-Cas9 mediated gene editing in induced pluripotent stem cells became an efficient tool to investigate biological mechanisms underlying genetic-driven diseases while accounting for the respective genetic background. This technique relies on the targeting of a specific nucleotide sequence presen...

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Bibliographic Details
Main Authors: Zoé Hanss, Ibrahim Boussaad, Javier Jarazo, Jens C. Schwamborn, Rejko Krüger
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Genetics
Subjects:
CRISPR-Cas9
GBA
pseudogene
GBAP1
iPSC
Parkinson’s disease
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.01297/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2019.01297/full

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